Dr Alistair P McGregor

Reader in Biology

Department of Biological and Medical Sciences - Faculty of Health and Life Sciences

Contact details

Phone number: +44 (0) 1865 484191
Email: amcgregor@brookes.ac.uk

Research activities

The themes of my research

Health and environment

My Research groups

Evolution of animal development and morphology

Arif, S., Murat, S., Almudi, I., Nunes, M. D.S., Bortolamiol-Becet, D., McGregor, N. S., Currie, J. M.S., Hughes, H., Ronshaugen, M., Sucena, E., Lai, E. C., Schlötterer, C., McGregor, A. P. (2013). Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster, Current Biology;23(6) DOI:10.1016/j.cub.2013.02.018
 
Hilbrant, M., Damen, W. G. M. and McGregor, A. P. (2012). Evolutionary crossroads in developmental biology: the spider Parasteatoda tepidariorum. Development 139, 2655-2662.
 
Posnien, N.*, Hopfen, C.*, Hilbrant, M., Ramos-Womack, M., Murat, S., Schönauer, A., Herbert, S. L., Nunes, M. D. S., Arif, S., Breuker, C. J., Schlötterer, C., Mitteroecker, P. and McGregor, A. P. (2012). Evolution of eye morphology and rhodopsin expression in the Drosophila melanogaster species subgroup. PLoS One 7, e37346. *Contributed equally.
 
Pechmann, M., Khadjeh, S., Turetzek, N., McGregor, A.P., Damen, W.G.M. and Prpic, N-M. (2011). Novel Function of distal-less as a gap gene during spider segmentation. PLoS Genetics 7, e1002342
 
Frankel, N., Erezyilmaz, D.F., McGregor, A.P., Wang, S., Payre, F., and Stern, D.L. (2011). Morphological evolution caused by many subtle-effect substitutions in regulatory DNA, Nature;474(7353) DOI:10.1038/nature10200
 
Janssen, R., Le Gouar, M., Pechmann, M., Poulin, F., Bolognesi, R., Schwager, E. E., Hopfen, C., Colbourne, J. K., Budd, G. E., Brown, S. J., Prpic, N. M., Kosiol, C., Vervoort, M., Damen, W. G. M., Balavoine, G. and McGregor, A. P. (2010). Conservation, loss, and redeployment of Wnt ligands in protostomes: implications for understanding the evolution of segment formation. BMC Evolutionary Biology 10, 374.
 
Murat, S., Hopfen., C. and McGregor, A. P. (2010). The function and evolution of Wnt genes in arthropods. Arthropod Structure and Development 39, 446-452.
 
Shigenobu, S., Bickel, R. D., Brisson, J. A., Butts, T., Chang, C., Christiaens, O., Davis, G. K., Duncan, E. J., Ferrier, D. E. K., Iga, M., Janssen, R., Lin, G., Lu, H., McGregor, A. P., Miura, T., Smagghe, G., Smith, J. M., van der Zee, M., Velarde, R., Wilson, M. J., Dearden, P. K. and Stern, D. L. (2010). Comprehensive survey of developmental genes in the pea aphid, Acyrthosiphon pisum: frequent lineage-specific duplications and losses of developmental genes. Insect Molecular Biology 19, 47-62.
 
Schwager, E. E., Pechmann, M., Feitosa, N. M., McGregor, A. P. and Damen, W. G. M. (2009). hunchback functions as a segmentation gene in the spider Achaearanea tepidariorum. Current Biology 19, 1333-1340.
 
McGregor, A. P., Pechmann, M., Schwager, E. E. and Damen, W. G. M. (2009). An ancestral regulatory network for posterior development in arthropods. Communicative and Integrative Biology 2, 174-176.
 
Pechmann, M., McGregor, A. P., Schwager, E. E., Feitosa, N. M. and Damen, W. G. M. (2009). Dynamic gene expression is required for anterior regionalization in a spider. Proceedings of the National Academy of Sciences USA 106, 1468-1472.
 
McGregor, A. P.*, Pechmann, M.*, Schwager, E. E., Feitosa, N. M., Kruck, S., Aranda, M. and Damen, W. G. M. (2008). Wnt8 is required for establishment of the growth zone and development of opisthosomal segments in a spider. Current Biology 18, 1619-1623.
*Contributed equally.
 
Hermisson, J. and McGregor, A. P. (2008). Pleiotropic scaling and QTL data. Nature 456, E3-E4.
 
Gregor, T.*, McGregor, A. P.* and Wieschaus, E. F. (2008). Shape and function of the Bicoid morphogen gradient in dipteran species with different sized embryos. Developmental Biology 316, 350-8.
*Contributed equally.
 
McGregor, A. P., Hilbrant, M., Pechmann, M., Schwager, E. E., Prpic, N. M. and Damen, W. G. (2008). Cupiennius salei and Achaearanea tepidariorum: Spider models for investigating evolution and development. Bioessays 30, 487-98.
 
Gregor, T., Wieschaus, E. F., McGregor, A. P., Bialek, W. and Tank, D. W. (2007). Stability and nuclear dynamics of the Bicoid morphogen gradient. Cell 130, 141-152.
 
McGregor, A. P., Orgogozo, V., Delon, I., Zanet, J., Srinivasan, D. G., Payre, F. and Stern, D. L. (2007). Morphological evolution through multiple cis-regulatory mutations at a single gene. Nature 448, 587-590.
 
McGregor, A. P. (2006). Wasps, beetles and the beginning of the ends. Bioessays 28, 683-686.
 
Wratten, N. S.*, McGregor, A. P.*, Shaw, P. J. and Dover, G. A. (2006). Evolutionary and functional analysis of the tailless enhancer in Musca domestica and Drosophila melanogaster. Evolution and Development 8, 6-15.
*Contributed equally.
 
McGregor, A. P. (2005). How to get ahead: the origin, evolution and function of bicoid. Bioessays 27, 904-13.
 
Shaw, P. J., Wratten, N. S., McGregor, A. P. and Dover, G. A. (2002). Co-evolution in bicoid-dependent promoters and the inception of regulatory incompatibilities among species of higher Diptera. Evolution and Development 4, 265-277.
 
McGregor, A. P., Shaw, P. J. and Dover, G. A. (2001). Sequence and expression of the hunchback gene in Lucilia sericata: a comparison with other Dipterans. Development, Genes and Evolution 211, 315-8.
 
McGregor, A. P., Shaw, P. J., Hancock, J. M., Bopp, D., Hediger, M., Wratten, N. S. and Dover, G. A. (2001). Rapid restructuring of bicoid-dependent hunchback promoters within and between Dipteran species: implications for molecular co-evolution. Evolution and Development 3, 397-407.
 
Shaw, P. J., Salameh, A., McGregor, A. P., Bala, S. and Dover, G. A. (2001). Divergent structure and function of the bicoid gene in Muscoidea fly species. Evolution and Development 3, 251-62.

 

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