Dr Sue Vaughan

Senior Lecturer in Cell and Molecular Biology

Department of Biological and Medical Sciences - Faculty of Health and Life Sciences

Contact details

Phone number: +44 (0)1865 483254
Email: svaughan@brookes.ac.uk

Research activities

Details of my research

Cell biology of trypanosomes


Selected Publications

  • Hughes L, Hawes C, Monteith S, Vaughan S (2013). Serial block face scanning electron microscopy-the future of cell ultrastructure imaging. Protoplasma. Nov 17. [Epub ahead of print]
  • Wheeler RJ, Scheumann N, Wickstead B, Gull K, Vaughan S (2013) Cytokinesis in Trypanosoma brucei differs between bloodstream and tsetse trypomastigote forms: implications for microtubule-based morphogenesis and mutant analysis.
    Mol Microbiol. doi: 10.1111/mmi.12436.
  • Hughes L, Towers K, Starborg T, Gull K, Vaughan S (2013) A cell body groove housing the new flagellum tip suggests an adaptation of cellular morphogenesis for parasitism in bloodstream form Trypanosoma brucei. J Cell Sci. 2013 Oct 14. [Epub ahead of print]
  • André J, Harrison S, Towers K, Qi X, Vaughan S, McKean PG, Ginger ML (2013).Tubulin-binding cofactor C domain-containing protein TBCCD1 orchestrates cytoskeletal filament formation. Cell Sci. 2013 Oct 7. [Epub ahead of print]
  • Lacomble S, Vaughan S, Deghelt M, Moreira-Leite FF, Gull K (2012) A Trypanosoma brucei protein required for maintenance of the flagellum attachment zone and flagellar pocket ER domains. Protist. Jul;163(4):602-15.
  • Brandon S. J. Davies, Chris N. Goulbourne, Richard H. Barnes, Kirsten A. Turlo, Peter Gin, Sue Vaughan, David J. Vaux, André Bensadoun, Anne P. Beigneux, Loren G. Fong, and Stephen G. Young (2012). Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. J Lipid Res. 53(12):2690-7.
  • Lacomble S, Vaughan S, Deghelt M, Moreira-Leite FF, Gull K (2012). A Trypanosoma brucei protein required for maintenance of the flagellum attachment zone and flagellar pocket ER domains. Protist. 2012 Jul;163(4):602-15.
  • Sue Vaughan and Helen R. Dawe (2011). Common Themes in Centriole and Centrosome Movements. Trends Cell Biol. 21(1):p57-66.
  • Johanna L Hoog, Eva Gluenz, Sue Vaughan and Keith Gull (2010). Ultrastructural Investigation Methods of Trypanosoma brucei. Methods Cell Biol. Vol 96, p175-196.
  • Lacomble S, Vaughan S, Gadelha C, Morphew MK, Shaw MK, McIntosh JR, Gull K (2010). Basal body movements orchestrate membrane organelle division and cell morphogenesis in Trypanosoma brucei. J. Cell Sci. 123(Pt 17): p2884-91
  • Sue Vaughan (2010). Assembly of the flagellum and its role in cell morphogenesis in Trypanosoma brucei. Curr Opin Microbiol. Aug;13(4):453-458.
  • Lacomble S, Vaughan S, Gadelha C, Morphew MK, Shaw MK, McIntosh JR, Gull K (2009).Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography. J Cell Sci. (Pt 8):1081-90.
  • Olego-Fernandez S, Vaughan S, Shaw MK, Gull K, Ginger ML (2009). Cell morphogenesis of Trypanosoma brucei requires the paralogous, differentially expressed calpain-related proteins CAP5.5 and CAP5.5V. Protist. p576-90.
  • Vaughan S and Gull K (2008) The structural mechanics of cell division in Trypanosoma brucei. Biochem. Soc. Trans. 421-4.
  • Sue Vaughan, Linda Kohl, Ian Ngai, Richard Wheeler and Keith Gull (2008). A repetitive protein essential for the flagellum attachment zone filament structure and function in Trypanosoma brucei. Protist 59(1):127-36.
  • Sue Vaughan, Angela Stephan, Mike Shaw, Keith Gull and Paul G. McKean (2007). An essential Quality Control Mechanism at the Eukaryotic Basal Body Prior to Intraflagellar Transport. Traffic 8 (10): 1323-30.
  • Sue Vaughan, Mike Shaw, and Keith Gull (2006). A post-assembly structural modification to the lumen of flagellar microtubule doublets. Curr. Biol., 16, 449-450.
  • Andrew P Jackson, SueVaughan and Keith Gull (2006). Evolution of tubulin gene arrays in Trypanosomatid parasites: genomic restructuring in Leishmania. BMC Genomics, 18 , 7 261.
  • Andrew P Jackson, Sue Vaughan and Keith Gull (2006). Comparative genomics and concerted evolution of β-tubulin paralogs in Leishmania spp. BMC genomics, 6, 7, 137.
  • Gareth W. Morgan, Paul W. Denny, Sue Vaughan, David Goulding, Tim R. Jeffries, Deborah F. Smith, Keith Gull and Mark C. Field (2005). An Evolutionarily Conserved Coiled-Coil Protein Implicated in Polycystic Kidney Disease Is Involved in Basal Body Duplication and Flagellar Biogenesis in Trypanosoma brucei. Mol. Cell. Biol., 3774-3783.
  • Karen Sheader, Sue Vaughan, James Minchin, Katie Hughes, Keith Gull and Gloria Rudenko (2005). Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes. PNAS 102, 8716-8721.
  • Sue Vaughan, Bill Wickstead, Keith Gull and Stephen G. Addinall (2004). Molecular Evolution of FtsZ Protein Sequences Encoded Within the Genomes of Archaea, Bacteria, and Eukaryota. J. Mol. Evol., 58, 19-39.
  • Laura J. Briggs, Paul G. McKean, Andrea Baines, Flavia Moreira-Leite,, Jacqueline Davidge, Sue Vaughan and Keith Gull (2004). The flagella connector of Trypanosoma brucei: an unusual mobile transmembrane junction. J. Cell Sci. 117, 1641-1651.
  • Paul G. McKean, Andrea Baines, Sue Vaughan and Keith Gull (2003). -Tubulin Functions in the Nucleation of a Discrete Subset of Microtubules in the Eukaryotic Flagellum. Curr. Biol, 13, 596-602.
  • Sue Vaughan and Keith Gull (2003). The trypanosome flagellum. J. Cell Sci 116, 757-759. 
  • Paul G. McKean, Sue Vaughan and Keith Gull (2001). The extended tubulin superfamily J. Cell Sci. 114, 2723-2733.
  • Susan Vaughan, Teresa Attwood, Miguel Navarro, Valerie Scott, Paul McKean and Keith Gull (2000) New tubulins in protozoal parasites. Curr. Biol. 10, 7, 258-259.

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